Efficient delivery of Antiepileptic Drugs (AED’s) and Nanomedicine for the treatment of epilepsy

Abstract

A common brain disorder affecting people of all age groups is epilepsy. It is characterized by development of seizures. To control the frequency of seizures a broad group of AED’s (Antiepileptic drugs) were given. Epilepsy is a neurological disorder. The limited solubility and accessibility of AEDs across the blood brain barrier (BBB) have limited their oral administration. Because of their long-term drug release, low toxicity, and biocompatibility, nanomaterials were employed to administer AEDs. This paper describes about different types of AED’s and their structure, mechanism of action, and treatment of epilepsy using nanocarrier via blood brain barrier. Nanomaterials cross the BBB and used barrier for the diagnosis of epilepsy. This paper describes about various AED’s and nanomedicines for the treatment of epilepsy. Nanomaterials have been developed for efficient delivery of AED’s as well as imaging agents into CNS. These nanomedicines easily cross BBB to diagnose epilepsy. The intranasal administration route is more efficient way to deliver nanoagents for diagnosis of epilepsy.